Weekly Brief, 2 October 2023

This week's highlights

Webinar: Increasing capacity in impact evaluation in a life science research infrastructure

3 October 2023 | 12:00-13:00 CEST | Online

This ELIXIR impact webinar will present the outcomes of the project "Impact evaluation at Node-level - getting it done", funded by ELIXIR-CONVERGE and ELIXIR. The project aimed to increase capacity in impact evaluation across a set of national ELIXIR Nodes.

More information and registration

Recommended reads

Extending inherited metabolic disorder diagnostics with biomarker interaction visualizations

An EJP RD paper

Inherited Metabolic Disorders are rare diseases where one impaired protein leads to a cascade of changes in the adjacent chemical conversions. IMDs often present with non-specific symptoms, a lack of a clear genotypephenotype correlation, and de novo mutations, complicating diagnosis. Visualization of the connections between metabolic biomarkers and the enzymes involved might aid in the diagnostic process. The goal of this study was to provide a proof-of-concept framework for integrating knowledge of metabolic interactions with real-life patient data before scaling up this approach. The lessons learned from the approach will help to scale up the framework and support the diagnosis of other less-understood IMDs.

Read more

Therapeutic Potential of Tumor Metabolic Reprogramming in Triple-Negative Breast Cancer

An ELIXIR-HU supported research

Triple-negative breast cancer is the most aggressive subtype of breast cancer, with clinical features of high metastatic potential, susceptibility to relapse, and poor prognosis. A better understanding of the interaction between the tumor microenvironment and tumor cells, and the underlying molecular mechanisms of cellcell communication signaling, may uncover additional targets for better therapeutic strategies in TNBC treatment. In this review, the authors aim to discuss the mechanisms in tumor metabolic reprogramming, linking these changes to potential targetable molecular mechanisms to generate new, physical science-inspired clinical translational insights for the cure of TNBC.

Read more

Updates from Nodes

ELIXIR-UK at the 2nd International Research Software Funders Workshop

The 2nd International Research Software Funders Workshop, organised by the Research Software Association (ReSA) and Digital Research Alliance of Canada took place in Montreal 19-20 September as a hybrid meeting, with satellite workshops on Software Citation and Funder Strategies for Support Research Software.

Carole Goble, the ELIXIR-UK Joint Head of Node, gave a workshop's opening talk. These workshops have led to the ADORE declaration on Funding Research Software Sustainability.

Check the presentation

5th Hands-on Computational Enzyme Design Course

12-14 February 2024 | Online

The interactive course will provide essential theory on different areas of enzyme engineering, and hands-on experience with several software tools suitable for mining new enzymes, engineering the activity and solubility of enzymes. The participants will have the chance to learn from the developers and experienced users of these tools, and discuss the optimal ways to set up calculations and adequately interpret the results.

More information and registration

Updates from Platforms

Data & Interoperability Joint F2F (Hybrid)

21-23 November 2023 | Hybrid - Amsterdam, the Netherlands

Data & Interoperability Platforms will host their joint face-to-face/hybrid event on 2123 November 2023. The Platform is planning to have a more dynamic and interactive meeting this year, please stay tuned to the website for the agenda.

More information and registration

Updates from Communities

 

Register for the Metabolomics Community and Industry F2F/hybrid Meeting

16-18 October 2023 | Hybrid - Heidelberg, Germany

Registration deadline: 03 October (f2f) | 15 October (online)

The meeting combines the Metabolomics Community F2F as well as a metabolomics industry meeting. The first part will focus on Community activities and possibly an updated white paper/roadmap. The second part will focus on metabolomics industry relations, and includes industry representatives from across the world.

Find out more and register now

Updates from other initiatives

EUCAIM Unveils First Release Of Groundbreaking Platform

The EUCAIM consortium and the European Commission are excited to announce the first public release of its platform, Cancer Image Europe, marking a major milestone in the projects development and an exciting step towards achieving its vision and goals. The first platform release brings benefits to researchers, clinicians and AI innovators across Europe and paves the way for the future of cancer diagnosis and treatment.

Read more

FAIR-IMPACT's second open call for support

Applications are being accepted for FAIR-IMPACT's second open call for support. Successful applicants will work with one-to-one support from FAIR-IMPACT mentors to self-assess their current FAIR-enabling capabilities, to develop FAIR implementation action plans and to define engagement strategies. There are three support programmes being offered in this call:

• Support for National Level Initiatives
• Support for Research Performing Organisations
• support for Repositories and Data Service Providers

Applications will be accepted via our grants platform until 1 November 2023.

More details and recordings of the introductory online workshops

Upcoming ELIXIR events & webinars

ELIXIR Training Courses & Webinars

The ELIXIR TeSS portal has a variety of interesting events and courses organised by the ELIXIR Nodes. For more, visit TeSS portal

BioSB course: Algorithms for Genomics
9-13 October 2023 | Delft, the Netherlands

ELIXIR Events and Conferences

Metabolomics Joint Community and Industry F2F/hybrid meeting
16-18 October 2023 | Heidelberg, Germany

Single Cell Omics Community F2F/hybrid meeting
18-20 October 2023 | Hinxton, UK

BioHackathon Europe 2023
30 October - 3 November 2023 | Barcelona, Spain

3D BioInfo Community meeting
15-17 November 2023 | Hybrid - Prague, Czech Republic

Federated human data (FHD) Community meeting
16-17 November 2023 | Hybrid - Barcelona, Spain

ELIXIR hCNV Community F2F/hybrid meeting
30 November-1 December 2023 | Hybrid - Hinxton, UK

Job vacancies

All vacancies are also published on the ELIXIR website (also including those from industry). If you need our help communicating your new open positions, you can submit a job advertisement and it will automatically appear on our newsletters. Go to our vacancy page to submit a job
 

Bioinformatician / Research Software Engineer (m/f/d) "Databases for molecular pathogen data"

Leibniz Institute DSMZ

Bioinformatics Software Developer in Protein Structure and Genetic Variant Modelling

Imperial College London

Legal & Ethics Officer

ELIXIR Hub

Bioinformatician for Metabolic Pathway Reconstruction

Leibniz Institute DSMZ

Data Steward

Luxembourg National Data Service