3D-BioInfo Webinar: Infrastructure and Functional Annotations

to
GMT

Spain

You are invited to join the first webinar of 2025 run by the 3D-BioInfo Community. 

 

Speaker:

Prof. David Jones

University College London, United Kingdom

Abstract

The AlphaFold Protein Structure Database (AFDB) contains more than 214 million predicted protein structures composed of domains, which are independently folding units found in multiple structural and functional contexts. Identifying domains can enable many functional and evolutionary analyses but has remained challenging because of the sheer scale of the data. Using deep learning methods, we have detected and classified every domain in the AFDB, producing The Encyclopedia of Domains. We detected nearly 365 million domains, over 100 million more than can be found by sequence methods, covering more than 1 million taxa. Reassuringly, 77% of the nonredundant domains are similar to known superfamilies, greatly expanding representation of their domain space. We uncovered more than 10,000 new structural interactions between superfamilies and thousands of new folds across the fold space continuum.

This is part of a continuing series building on the success of previous years, recordings of which are available here 

Speakers
Prof. David Jones (University College London, United Kingdom)